THE ORAL BIOAVAILABILITY OF FUMONISIN B1 IS REDUCED BY AN ANTI MYCOTOXINS AGENT IN BROILER CHICKENS IN A TOXICOKINETIC STUDY 

Insaf Riahi1, Meritxell Sadurní1, Raquel Codina1, Ignacio Montagud1, Diethard Reckelbus2, Tine Desomer2, Jelle Lambrecht2, Gemechu Zeleke Iticha2,  Amelie Catteuw2, Sofie Rutjens2, Siska Croubels2 

1 Technical Department, BIŌNTE Nutrition, Reus, 43204, Tarragona, Spain 

2 Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium

INTRODUCTION

Toxicokinetic studies are necessary to evaluate the efficacy of mycotoxin detoxifiers, considering the possible effects on the oral absorption and disposition of the mycotoxins in broiler chickens. The detoxification capacity of mycotoxins binder for fumonisin B1 (FB1) is rather limited. 

OBJECTIVE

The aim of the present study was to determine the effects of an anti-mycotoxins agent based on minerals, phytogenics and organic components on the plasma concentration-time profile of FB1 in broiler chickens.

MATERIALS AND METHODS

RESULTS

CONCLUSIONS

The anti-mycotoxins agent containing minerals, phytogenics and organic components reduced the oral absorption of fumonisin B1, being efficient in reducing the total systemic exposure to fumonisin B1 in broiler chickens.