INTRODUCTION
Inflammation is a critical physiological immune response that protects the host against pathogens and harmful stimuli. However, excessive or chronic inflammation can compromise gut epithelial integrity, impair nutrient absorption, and reduce growth and overall health. Immunomodulatory strategies, such as supplementation with purified natural extracts rich in bioactive compounds, have been shown to effectively control inflammation, improve intestinal health, and support animal performance (Abd El-Hack et al., 2023).
OBJECTIVE
Evaluate the in vitro immunostimulatory activity of a liquid solution (LS) based on grape and olive extracts for poultry nutrition. The activity of the product was evaluated in a co-culture model of intestinal cells by measuring pro- and anti-inflammatory cytokine production.
MATERIALS AND METHODS
RESULTS
The liquid formulation based on grape and olive extracts significantly reduced the levels of the pro-inflammatory cytokines IL-6 and TNF-α, while increasing the levels of the anti-inflammatory cytokine IL-10 compared with the inflammatory control. These effects were observed both in the treatment of inflammation and in the preventive treatment prior to inflammatory induction.
CONCLUSIONS
The solution based on natural extracts has therapeutic and preventive anti-inflammatory effects, effectively modulating pro- and anti-inflammatory cytokines in gastrointestinal cells exposed to pathogenic bacteria, thereby contributing to enhance intestinal health and poultry performance.
